What do we need to change about biosecurity governance, and how should we do that? In a recent webinar hosted by Issues in Science and Technology and the Consortium for Science, Policy, & Outcomes, I sat down (well, virtually at least) with Melissa Haendel (University of Colorado Anschutz Medical Campus), David Gillum (Arizona State University), and Yong-Bee Lim (Council on Strategic Risks) discussed how to reimagine biosecurity and biosafety—and even the relationship between biological research and society—for a new era. The conversation was moderated by Bryan Walsh (Vox Future Perfect), and we can rewatch it here.